Expert Scientist, Physical and Chemical Analysis

Company: GlaxoSmithKline
Location: Rockville
Posted on: May 26, 2023

Job Description:

Site Name: USA - Maryland - RockvillePosted Date: Jan 25 2023We are delighted that we recently signed a contract to expand our space at Cambridge Park Drive (CPD Cambridge, MA) significantly. The expansion of the CPD facility is focused primarily on lab space and will bring together talent and expertise, especially to focus on cutting edge technologies. The lease for Rockville Vaccines site, where this role is currently being recruited, will expire by Q2 2026 and we have decided not to renew the lease. Consequently, this lab-based role may be relocated to Boston, Massachusetts in 2025.Are you energized by the challenge of improving human health by developing vaccines? If so, this Expert Scientist opportunity could be an exciting opportunity to consider.Within the Analytical Research and Development, Expert Scientist, in Physical & Chemical Analytics group, will serve as Subject Matter Expert (SME) in LC-MS and biophysical analyses of mRNA and protein antigens. The scientist will be responsible for characterizing antigens and their interactions using mass spectrometry and an array of biophysical and traditional protein chemistry tools. This role is focused on providing a structure-function understanding to support assay development activities for all stages of vaccine development. The role will also provide YOU the opportunity to lead key activities to progress YOUR career in science and people management, these responsibilities include some of the following:

• Lead the LC-MS platform by ensuring state-of-the art mass spectrometry equipment and software are being used and evaluated in a continuous improvement manner
• Provide support to junior scientists and mentor them for their technical development and implementation of innovative solutions for new applicationsin mass spectrometry.
• Ensure that mass spectrometers settings are harmonized and maintained for intended use and that the instruments are calibrated accordingly
• Present LC-MS data in Analytical Sub-Team (AST) meetings and cross-function meetings
• Assist lab head in recruiting junior scientists
• Write characterization report or provide data as requested by Analytical Project lead (APL)Why you?Basic Qualifications: We are looking for professionals with these required skills:
  • PhD or Master's degree with specialization in Mass Spectrometry
  • At least 6+ years of experience in industry/academic (pharmaceutical or biotech) setting working on characterizing diverse molecules (proteins, carbohydrates, nucleotides) by mass spectroscopy and spectrophotometry
  • Two or more years of experience with analytical development for vaccine/ biotherapeutic candidates.
  • Two or more years of experience working in protein and nucleic acid chemistry and strong laboratory skills
  • Two or more years of hands-experience with qualitative and quantitative characterization of proteins and nucleotides using MS platform (Glycan profiling, peptide mapping, intact mass, 5' capping and 3' PolyA assays).Preferred Qualifications:If you have the following characteristics, it would be a plus:
    • Familiarity with HDX for higher order structure determination, epitope / paratope mapping.
    • Knowledge and experience with Quality by Design, Process Analytical Technology, CMC, regulatory filling, and managing CMC program
    • Experience with, liquid handling systems, and robotic automationWhy GSK?Uniting science, technology and talent to get ahead of disease togetherGSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued and included. Where they can keep growing and look after their wellbeing.So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.#LI-GSKGSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting site.

Keywords: GlaxoSmithKline, Rockville , Expert Scientist, Physical and Chemical Analysis, Other , Rockville, Maryland