Scientist II - Downstream Process Development
Company: Charles River Laboratories, Research Models and Se
Posted on: May 14, 2022
Press Tab to Move to Skip to Content Link Location: - Rockville,
MD, US, 20850 Rockville, MD, US, 20850 Rockville, MD, US, 20852 For
70 years, Charles River employees have worked together to assist in
the discovery, development and safe manufacture of new drug
therapies. When you join our family, you will have a significant
impact on the health and well-being of people across the globe.
Whether your background is in life sciences, finance, IT, sales or
another area, your skills will play an important role in the work
we perform. In return, we'll help you build a career that you can
feel passionate about. Job Summary The Scientist II will apply
knowledge and expertise to design and execute downstream processes
for purification of biologics products and different types of viral
vectors such as adeno-associated virus (AAV), adenovirus,
lentivirus etc. The Scientist II will provide technical solutions
to a wide range of difficult problems. Duties and Responsibilities
--- Design and execute project specific process independently for
purification of different types of viral vectors including AAV,
lentivirus, adenovirus, and other biologics to meet the
requirements for specific projects in compliance with
--- Evaluate clients' process regarding feasibility and potential
risks for productivity and quality of products. Propose solutions
for improvement. -
--- Identify, source, and prepare appropriate materials according
to the project scope.
--- Execute different units of operations in downstream processes
including cell lysate clarification, chromatography using different
types of columns, and different filtration processes.
--- Lead assay development for in-process samples including but not
limited to viral titer assay by qPCR or HPLC, viral purity and
identity assay by SDS-PAGE silver staining and Western blot, and
other assays. -
--- Represent Process Development in providing solutions to
difficult technical issues associated with specific projects
internally and to clients.
--- Document all data in compliance with SOPs and provide help to
support IND documents based on client requirements.
--- Other responsibilities as needed. Job Qualifications
--- Ph.D. in Virology or Biochemistry, or related life science
field with 3+ years of related experience, or M.S. in a related
field with at least 5 years of experience.
--- Working experience with virus production is preferred.
--- Excellent verbal and written communication skills.
--- Microsoft Office experience (Word, Excel, PowerPoint,
--- Good critical thinking skills.
--- Ability to resolve customer issues.
--- Well-organized, able to manage multiple projects at a time.
--- Strong ability to adapt, be flexible, and work independently
and with resilience.
- Vaccine Mandate
Charles River is a U.S. Federal Contractor. As a result, we must
follow the Presidential Executive Order to mandate vaccinations,
and ensure our employees are fully vaccinated against COVID-19. Our
main priority is the wellbeing, health, and safety of our people.
We require proof of vaccination from all employees. -
Anyone with requests for disability-related and/or religious
exemptions should contact Talent Acquisition
(crrecruitment_US@crl.com) so that information can be provided
about the accommodation process at Charles River. About Biologics
With more than 50 years of experience and proven regulatory
expertise, the Charles River Biologics group can address
challenging projects for biotechnology and pharmaceutical companies
worldwide. Offering a variety of services such as contamination and
impurity testing, protein characterization, bioassays, viral
clearance studies and stability and lot release programs, we
support clients throughout the biologic development cycle, from the
establishment and characterization of cell banks through
preclinical and clinical studies to marketed products. Whether
clients need stand-alone services, a unique package of testing, or
insourced support, our Biologics group can create a custom solution
to suit their needs. Each year more than 20,000 biologic testing
reports are sent each and over 200 licenses products are supported
by our biologics testing solutions team.
About Charles River
Charles River is an early-stage contract research organization
(CRO). We have built upon our foundation of laboratory animal
medicine and science to develop a diverse portfolio of discovery
and safety assessment services, both Good Laboratory Practice (GLP)
and non-GLP, to support clients from target identification through
preclinical development. Charles River also provides a suite of
products and services to support our clients' clinical laboratory
testing needs and manufacturing activities. Utilizing this broad
portfolio of products and services enables our clients to create a
more flexible drug development model, which reduces their costs,
enhances their productivity and effectiveness to increase speed to
With over 18,000 employees within 100 facilities in over 20
countries around the globe, we are strategically positioned to
coordinate worldwide resources and apply multidisciplinary
perspectives in resolving our client's unique challenges. Our
client base includes global pharmaceutical companies, biotechnology
companies, government agencies and hospitals and academic
institutions around the world. -
At Charles River, we are passionate about our role in improving the
quality of people's lives. Our mission, our excellent science and
our strong sense of purpose guide us in all that we do, and we
approach each day with the knowledge that our work helps to improve
the health and well-being of many across the globe. We have proudly
supported the development of > 80% of the drugs approved by the
FDA for the past 3 years.
Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - all
qualified applicants will receive consideration for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, national origin, veteran or disability status.
If you are interested in applying to Charles River Laboratories and
need special assistance or an accommodation due to a disability to
complete any forms or to otherwise participate in the resume
submission process, please contact a member of our Human Resources
team by sending an e-mail message to crrecruitment_US@crl.com. This
contact is for accommodation requests for individuals with
disabilities only and cannot be used to inquire about the status of
applications. For more information, please visit
Nearest Major Market: Washington DC
Job Segment: Biochemistry, Scientific, Biotech, Scientist,
Pharmaceutical, Science, Engineering
Keywords: Charles River Laboratories, Research Models and Se, Rockville , Scientist II - Downstream Process Development, Other , Rockville, Maryland
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