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Principal Scientist, Process Sciences

Company: Amazon Workforce Staffing
Location: Rockville
Posted on: September 17, 2020

Job Description:

Principal Scientist, Process Sciences - TOQA2019R1044 Company: Alnylam Pharmaceuticals

Location: Cambridge

Posted on: September 12, 2020

Job Description:

National Postdoctoral Association Career Center PrincipalScientist, Process Sciences - TOQA2019R1044

AP Principal Scientist, Process Sciences - TOQA2019R1044 AlnylamPharmaceuticals

Cambridge, Massachusetts, United States

2 days ago

Description

Principal Scientist, Process Sciences

Overview

Alnylam is the world’s leading RNA interference (RNAi)company.

Founded in 2002, Alnylam was built upon a bold vision of turningscientific possibility into reality by harnessing the power of RNAifor human health as an innovative new class of medicines. We are agrowing biopharmaceutical company with two approved medicines and arobust pipeline of investigational medicines focused in fourstrategic therapeutic areas: genetic medicines, cardio-metabolicdiseases, infectious diseases, and central nervous system (CNS) andocular diseases, including several in late-stage development.Headquartered in Cambridge, Mass., Alnylam employs over 1,400people in 19 countries and is rapidly growing globally, withadditional offices in Norton, Mass., Maidenhead, U.K., Zug,Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam isproud to have been recognized as one of The Boston Globe’s TopPlaces to Work five years in a row (2015-2019), a Great Place toWork in the U.K. and Switzerland in 2020 and Science Magazine’s #1Top Employer in 2019. Please visit www.alnylam.com for moreinformation.

The successful candidate will be a part of the Process andAnalytical Sciences group. Responsibilities will include processdevelopment, in-house non-GMP manufacturing process transfer toCMOs, and stage 1 manufacturing process validation for siRNAoligonucleotides .

Summary of Key Responsibilities

Leading oligonucleotide manufacturing process development,optimization and scale up

Participating in in-process analytical method development andoptimization

Managing oligonucleotide APIs manufacture in non-GMPenvironment

Authoring process description, technical protocols and reports.Leading process transfer activities and providing timely technicalsupport for GMP productions.

Drafting/Reviewing SOPs and manufacturing documents according toregulatory and procedural guidelines. Supporting processcharacterization activities.

Working closely with manufacturing, AD/QC, QA teams and CMO/CROin GMP manufacture and other CMC activities

Day-to-day lab operations and equipment maintenance

Requirements

Qualifications

Ph.D. with 5-7 years of experience in oligonucleotide chemistryor relevant areas. Experience in industrial settings ispreferred

Expertise in solid-phase synthesis and hands-on operationalknowledge with DNA/RNA automated solid-phase synthesizers isrequired.

Thorough understanding of process development approaches.Ability to integrate scientific findings/results across multipleareas of research or development projects.

Knowledge of the analytical and purification techniques foroligonucleotides, and oligonucleotide-conjugates is preferred.

Good verbal and written communication skills are a must

Alnylam Pharmaceuticals is an EEO employer committed to anexciting, diverse, and enriching work environment.

#LI-CF1

Job Information

Job ID: 54481738

Location:

Cambridge, Massachusetts, United States

Position Title: Principal Scientist, Process Sciences -TOQA2019R1044

Company Name: Alnylam Pharmaceuticals

Job Function: Scientist

Job Type: Full-Time

Job Duration: Indefinite

Min Education: Ph.D.

Min Experience: 5-7 Years

Required Travel: None

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15800 Crabbs Branch Way, Rockville, Maryland 20855 (301)984-4800

Keywords: Alnylam Pharmaceuticals, Cambridge , Principal Scientist, Process Sciences - TOQA2019R1044, Other , Cambridge, Massachusetts

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