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Scientist II / Research Manager I

Company: MacroGenics, Inc.
Location: Rockville
Posted on: September 14, 2023

Job Description:

MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of -350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer.Our products and platforms have attracted multiple partnerships with leading pharmaceutical -and biotechnology -companies around the globe. -MacroGenics is a bold, highly engaged, and diverse team driven by a passion for improving the lives of patients through innovative science. We are committed to an inclusive workplace built on trust and respect. We value and nurture strong connections with one another and foster collaborative relationships. We empower our people and drive personal accountability. We encourage curiosity and -embrace our entrepreneurial spirit. We celebrate our successes and create a learning environment where all employees can thrive! -Summary of Position -The Scientist II / Research Manager I Mass Spectroscopist is a hands-on laboratory position in the protein chemistry group within the Antibody Engineering department. The primary responsibilities of the position are characterizing monoclonal and bispecific antibodies and their targets and maintaining the mass spectrometer. This individual will interact with multiple cross functional teams and support the drug discovery and development of MacroGenics' pipeline of preclinical and clinical programs.Responsibilities and Job Duties

  • Support the research discovery pipeline by helping to ensure quality deliverables to upstream and downstream groups running assays for the selection of lead drug molecules.
  • Confirm the identities of multi-chain protein drug candidates prior to investing valuable resources running biological assays and in vivo studies.
  • Identify proteolysis products to assist the protein purification scientists with in-process purification support.
  • Make recommendations to project teams regarding the feasibility of developing drug molecules by characterizing carbohydrates and analyzing tryptic peptides for post-translational modifications including oxidation products, deamidation, and aspartic acid isomerization.
  • Conduct epitope mapping of antigen-antibody complexes using mass spectrometry for differentiating antibody molecules for selecting lead molecules.
  • Work closely with the mass spectroscopy group in Development to ensure a smooth transition of molecules from Research to Development -Minimum QualificationsScientist II:Education & Experience
    • Ph.D. in biochemistry, biophysics, or equivalent scientific field of study
    • Minimum of two years biotechnology or pharmaceutical industry experience
    • Experience working with antibodies
    • Prior experience with the maintenance of mass spec instrumentEducation & Experience
      • MS or BS in biochemistry, biophysics, or equivalent scientific field of study.
      • Minimum of 7 years (MS) or 10 years (BS) biotechnology or pharmaceutical industry experience.
      • Experience working with antibodies
      • Prior experience with the maintenance of mass spec instrument Knowledge, Skills and Abilities
        • Strong background in protein mass spectroscopy
        • Experience with Waters Xevo G2-S QTOF and UNIFI software
        • Strong knowledge of Antibodies and bispecific drug molecules
        • Must be flexible when there are unplanned requests for mass spectrometry support for troubleshooting protein purification processes
        • Knowledge of state-of-the-art technologies in mass spectrometry
        • Excellent communication skills and ability to work in cross-functional teams
        • Excellent organization and multi-tasking skills -Supervisory Responsibilities:NonePreferred Qualifications
          • Experience with protein Biophysical chemistry in a professional setting
          • Experience with Protein biochemistry in a professional setting
          • Desire to expand scientific skill sets in protein biochemistry to support other functional areas within the team.StatementMacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email or call (301) 354-3566 and/or 711 for TTD/TTY service. -Equal Opportunity Employer/Veterans/DisabledWe do not accept non-solicited resumes or candidate submittals from search/recruiting agencies.

Keywords: MacroGenics, Inc., Rockville , Scientist II / Research Manager I, Executive , Rockville, Maryland

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