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Senior Scientist - Protein Engineering

Company: Immunomic Therapeutics, Inc.
Location: Rockville
Posted on: June 13, 2022

Job Description:

Senior Scientist - Protein EngineeringJob Code: 2022 RD005 JOB DESCRIPTIONImmunomic Therapeutics is hiring to support the discovery and development of novel antibody therapeutics building and expanding from the UNITE Platform. Our Company is a top-tier, pre-IPO biopharmaceutical company. We have collaborative relationships with premier academic labs including Duke University, University of Florida and The Johns Hopkins University. This position will focus on the design, generation, optimization, and characterization of protein-based modalities (including antibodies) to enable the development of effective therapies for immune-related disorders including cancer and autoimmune disease. You will assume a leadership role on projects and be responsible for the achievement of group goals predominantly through collaborative relationships with CROs as well as hands-on experimentation and data analysis. You will collaborate with multi-disciplinary teams to prioritize product candidates for protein generation and coordinate biological characterization and validation of molecules both in vitro and in vivo. The ideal candidate will be a motivated, collaborative and innovative scientist with a proven ability to solve complex problems, who has the drive and self-motivation to work as a leader in an expanded field of discovery and establish protein engineering (antibody development) as an internal function while contributing significantly and directly to the development of therapies for patients in need. This position reports to the CSO.ESSENTIAL FUNCTIONSLead protein engineering and antibody development efforts in the design of advanced next generation biopharmaceuticals including management of CRO advanced antibody library screening and novel proprietary sequence development. Lead recombinant protein production both in-house and utilizing CRO's.Independently design antibody and recombinant protein structures and protein sequences for evaluation in robust manufacturable mammalian expression systems. Responsible for molecular biology and vector construction including cell line construction for screening of design molecules.Work as a team with discovery research teams to characterize target specificity and activity of lead molecules with cell binding and cell signaling assays using flow cytometry and other invitro technologies.Assess recombinant protein quality attributes and manufacturability: such as stability, purity, heterogeneity, and activity through assays including cGE, cIEF, analytical SE, IEX, RP HPLC/UPLC), MALS, direct binding (Affinity and binding kinetics characterization) of lead molecules.Protein modeling including structural analysis and protein:protein docking.Design and execute experiments, analyze data, and troubleshoot methods.Maintain up-to-date lab notebook.Coordinate with cross-functional teams on the biological characterization of designed molecules; build consensus around candidates and take a leadership role in data driven decision making through the assessment of data and evaluation of results.Communicate experimental design and results to team members and present updates. COMPETENCIES AND SKILLSCustomer FocusCommunication/Presentation Skills (spoken, written)Integrity/EthicsInitiativeSense of UrgencyTeamworkCollaboration SkillsInnovationREQUIRED EDUCATION AND EXPERIENCEPh.D. in Biochemistry, Chemistry, Biological Physics, Structural Biology, or related discipline with 5-10 years post-graduate experience in industry or academia.Detailed knowledge of and experience in antibody library screening, antibody development, protein design and engineering.A working knowledge of Immunology and immune cell engagement, including antibody structure/function relationships is preferred.Must have experience with analysis of protein-protein interactions using BLI, SPR or other relevant technologies.Well-versed in molecular biology, cloning, subcloning, and construct design with extensive hands-on experience.Skilled in multi-color flow cytometry.Experience with mammalian protein expression.Extensive experience and track record in protein purification (affinity, IEX, SEC) with demonstrated ability to deliver high-quality, purified protein.Familiarity with or experience in any of the following is a plus: LC-MS (intact, petide map, S-S bond mapping), protein analytical and biophysical techniques including DLS, SEC-MALS HPLC, SPR, biolayer Interferometry, IEC-HPLC, RP-HPLC, protein formulation, protein production and purification.Antibody characterization including binding affinity, stability, epitope binning.Multi-specific antibody or bioconjugate generation and characterization.Results-oriented and the ability to work in a fast-paced and collaborative environment. Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.Please visit our careers site at Send your cover letter and credentials as described on the Careers page along with the Job Code: 2022 RD005 in the subject line.Equal Opportunity Employer

Keywords: Immunomic Therapeutics, Inc., Rockville , Senior Scientist - Protein Engineering, Engineering , Rockville, Maryland

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